Lung anti and pro apoptotic proteins. Understanding the moleculer

Lung cancer has become the one of the remarkable
threats to world  healthcare, with death rate of one out of four
deaths in both men and women. It is among one of cause of cancer related deaths
all over the world 1. Golbally lung cancer 
accounts for about 13 % of  new
cancer cases and 19 % fatality . In India, lung cancer accounts for 6.9 %
of  new 
cases and 9.3%  deaths in both
sexes, it is the commonest cancer and cause of cancer related mortality in
men,  and second most in women after
breast and ovarian carcinoma 2. Depending on tumour size and stages of lung
cancer several therapeutic regimens are available to treat lung cancer. Yet current
treatments like chemotherapy and radiation therapy are associated with several
adverse effects on the human system. Inspite of the progress in development  of several anticancer drugs, chemoresistance
is still major  obstacle that results
in the failure   of treatment3.
Multiple factors are involved in development of chemoresistance such as
inactivation of chemotherapy drug, alteration in tumor suppressor gene, anti
and pro apoptotic proteins. Understanding the moleculer role of tumor encoded
gene in development of drug resistance has great significance in development of
novel therapeutic target and also improve diagnosis4.

Tissue transglutaminase 2 (TG2)  is one of ubiquitously expressed protein
among 7 members of Tissue TG family. It is known to be involved in tumor
metastasis 5. It is distributed among major cell types and tissues and plays
a significant role in several biological processes. It take part in  post-translation modification  transamidase activity it is involved in
GTPase, ATPase, protein kinase, protein disulfide, and isomerase activity 6.

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 Overexpression of  TG2  leads to various pathological
disorders such as Alzheimer’s, Parkinson’s disease, multiple sclerosis,
celiac  along with tumour development
while Over expression of TG2is associated with malignant effects leading to
tumorigenesis, invasion, cell differentiation, and failure in apoptosis 7.As
a consequence, TG2 is known to have a significant impact in lung carcinoma,
especially towards non-small cell lung carcinoma 8. Targeting TG2 protein may
be valuable in identifying potential inhibitors against lung cancer. Numerous
natural compounds have been reported to have many biological activities as
antibacterial, antiviral and anti-cancer 9. Natural products and their
derivatives mimic over 50% of all the products that are being used. In the
present study an attempt is made in silico investigation of natural inhibitors
against TG2 from plant origin. The hit compounds obtained in this study could
play an important role in designing personalized therapy against lung cancer
patients.

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